PFMG

Precision diagnostics demand more than routine lab software. For PFMG, a laboratory offering a molecular test unlike any other in the world, off-the-shelf LIS solutions fell short. Their mission required software that could manage complex case logic, adapt to bespoke workflows, integrate securely with international networks, and scale without compromising data integrity. NucleoLIS provided the agility, modularity, and long-term partnership necessary to achieve all of the above.

In parallel, PFMG also expanded into anatomic pathology, selecting WindoPath—Psychē’s trusted AP LIS—to power their histopathology and tissue-based diagnostic operations. This multi-solution approach has allowed PFMG to maintain specialized environments optimized for both molecular and anatomic workflows, with centralized oversight across their broader network.

The Origin of a Unique Challenge PFMG came to market with an innovative molecular test performed at an extraordinarily high clinical and operational standard. The stakes were incredibly high. Clinical accuracy, data traceability, provider outreach, and global coordination were non-negotiable. They also started from scratch—a brand-new lab in need of a full LIS architecture.

After researching alternatives and receiving a referral, PFMG entered the “Build Your LIS” funnel through a Bing ad. Psychē Systems responded with a vision of what a fully tailored NucleoLIS deployment could achieve.

Selecting NucleoLIS: A Strategic Technology Partner From the beginning, PFMG made it clear that their lab would not conform to existing LIS limitations. Their workflows were novel, their case structures complex, and their client expectations high. Psychē embraced this challenge, offering:

• A new NucleoLIS Application & Database
• Full Build Services from the ground up
• Advanced Outreach Orders & Results functionality
• Initial instrument integration for molecular diagnostics

PFMG chose NucleoLIS not only for its functionality but also for the development partnership offered by Psychē—a partner that welcomed customization and iteration, rather than resisted it.

At the same time, PFMG evaluated solutions for their growing anatomic pathology service line. WindoPath stood out as a complementary LIS platform, designed specifically for AP workflows. It was implemented alongside NucleoLIS, ensuring unified data architecture but with discrete modules optimized for distinct diagnostic disciplines.

The Initial Build: Custom Architecture for a Custom Test In early 2022, PFMG and Psychē began work on the first phase of their NucleoLIS infrastructure. The foundation was designed to handle unusually complex reporting logic, highly detailed molecular datasets, and a workflow that had no prior LIS precedent.

The build included the development of case management structures that allowed for:

• Multi-step approvals across jurisdictions
• Conditional test progression based on interim results
• Extensive metadata tagging for each specimen
• Built-in escalation protocols for abnormal findings

The LIS was more than a tracking system—it became a digital choreography engine for test execution.

Layering In Precision: Workflow Design and Custom Development Over the first 18 months, PFMG expanded its system through continuous development and innovation. Each enhancement served a specific operational or clinical purpose:

• Custom interfaces for provider coordination
• Smart validation rules for genetic data accuracy
• Workflow trees tied to test pathways and regulatory requirements
• Case-level versioning to ensure compliance with international protocols

Rather than using generic modules, every enhancement was built with the test’s specific logic in mind. These improvements helped lab technicians minimize error, improve reproducibility, and manage each specimen with surgical precision.

Enhancing Outreach and Communication A test of this complexity can only be successful if communication is flawless. Psychē and PFMG expanded the LIS to include:

• Custom outreach modules for tailored report delivery
• Secure email functionality for HIPAA-compliant communication
• eDocs modules to manage international documentation

Outreach upgrades allowed clinicians across multiple countries to submit, monitor, and receive data in real time—without sacrificing clarity or security.

Long-Term Investment and Scalability PFMG’s LIS infrastructure reflects a long-term commitment to scalable growth, not just short-term utility. Their approach to platform development ensures that future needs—whether clinical, operational, or regulatory—can be met without disruption.

NucleoLIS’s modular design allows PFMG to evolve its molecular test workflows continuously, while WindoPath provides robust support for AP diagnostics within the same organization. The result is a dual-platform strategy that enables:

• Additional instrument integrations
• Expanded multi-lab routing workflows
• Integrated billing and claims handling
• Cross-border case auditing and compliance modules

Every upgrade has been strategically aligned with broader goals of excellence, reach, and innovation.

Lessons for Specialized and High-Stakes Labs PFMG’s success with NucleoLIS and WindoPath offers a clear message to labs operating at the frontier of diagnostics:

• Customization is not a luxury—it’s a necessity when tests fall outside the norm.
• Partnership matters. Choose a vendor who welcomes iteration and innovation.
• Compliance must be embedded into every layer of design.
• Scalability starts with architecture. Modular LIS platforms allow for building upward and outward without overhauling the system.
• One size rarely fits all. Deploying multiple purpose-built systems like NucleoLIS and WindoPath can offer specialization without fragmentation.

Conclusion: Built for Visionaries PFMG represents the kind of client NucleoLIS was built for: visionary, exacting, and unwilling to settle for generic solutions. Through three years of collaborative development, they have built an LIS that supports one of the most sophisticated diagnostic workflows in the world. With the addition of WindoPath for their AP lab, PFMG has demonstrated a clear commitment to building diagnostic infrastructure that’s as advanced and adaptable as the tests it supports.

If your lab is pioneering a specialty test, launching in a new country, or simply wants more from your LIS platform, PFMG’s journey proves what’s possible when flexibility meets focus. NucleoLIS and WindoPath aren’t just software—they’re platforms for those building what’s next.

Want to hear it straight from the lab? This Maryland-based lab is open to connecting with qualified peers interested in learning more about their journey. If you’d like an introduction, reach out to us at PsycheSystems.com.