Overview of NucleoLIS for Molecular Diagnostics

A fully automated solution designed to support and manage the unique workflow and complex reporting requirements of the clinical, molecular and genetic labs. NucleoLIS Ē.finity™ allows you to build and fully configure your specific test menus and workflows, supports rules-based logic for reflex testing and features highly customizable report formatting and distribution. You can now streamline the diagnostically diverse complexities of clinical, molecular and genetic testing.

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Platform Features


NucleoLIS handles all molecular diagnostic workflows including, but not limited to:

  • SARS-CoV-2 (COVID testing)
  • DNA Sequencing
  • Polymerase Chain Reaction (PCR)
  • Fluorescence in situ hybridization (FISH)
  • Karyotyping
  • Pharmacogenomics
  • Whole Exome Sequencing (WES)
  • Next-Generation Sequencing (NGS)\
  • Plus: Immunology, Toxicology, Surgical Anatomic Pathology P (AP), and more!

Laboratory Instrument Integration

  • Interface LIMS Software With Lab Instruments
  • Interface with any vendor according to their specifications – instruments, analyzers, labelers, digital imaging, Electronic Health Record (EHR) Systems, Hospital Information Systems (HIS), billing vendors, and more


  • Ask at Order Entry Questions: Require users to answer questions at order entry, based on case type, specimen, or profile/test.
  • Reflex Orders: Automatically place orders based on rules about your specimens, referring providers, case type, and more.
  • Automate and streamline workflows to increase efficiency and reduce costs

Sample Collection

  • End-to-end pathology specimen tracking system
  • Specimen Storage Manager: Track where and when specimens are stored for easy retrieval and access.


  • Reflex Testing at Accessioning: Order panels up front for faster turnaround times
  • Streamlined Accessioning: Enter orders easily based on medical record or accession number
  • Supports Familial Relationships: Link a complete patient history, including familial relationships, to enhance diagnostic and predictive outcomes.
  • Bar Code Capability: Compatible with most instruments used in the laboratory

Batch/Run Management

  • Create and manage batches or “runs” for analysis, including well plate assignment, mapping, and communication with automation platforms.
  • Ask at Order Entry Questions: Require users to answer questions at order entry, based on case type, specimen, or profile/test.
  • Worksheets: Create worksheets, such as plate maps, directly in NucleoLIS. Start from scratch or import an existing spreadsheet you currently use.


  • Detailed Audits: Easily access in-depth records of user activity
  • Instrument Review (IReview): Review results from instruments for quality assurance prior to releasing them into patients’ records.


  • Secure and HIPAA-compliant reports
  • Perform complex case search queries
  • Reports provided to help attest to CLIA and CAP required requirements, as well as other useful management reports
  • Tailor reports for your laboratory’s needs. Unlimited formats allow for unique styles based on physician, submitting group, case type, and more
  • CAP Synoptic – cancer reporting templates
  • Voice transcription – compatible with your preferred voice transcription tool
  • Release and retain all copies of reports – preliminary, final, and revised

Client Services Module

  • Client Services Module: Monitor and track your lab’s Quality Assurance
  • Billing Functionality: Automatically add charges based on specimen or profile/test type.

Seamless Updates

  • OneVersion ™ Structure: Enable new features as they become available, rather than waiting for costly and time-consuming upgrades.

What Our Customers Are Saying

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“My only regret is that due to time constraints here, I have spent less time working with the system than I would have liked post-live operations. The capabilities are much better as a molecular LIS. The workflow and features are built for molecular. I don’t feel we have even scratched the surface of what we could do with it as we continue using all of the features, but what we do use it for works very well for our lab and our staff.

“The flexibility is so good (we frequently add new types of tests and workflows) and it is really easy with the build and the report formatter to add to and whip something up and put it in use very quickly.

“nucleoLIS and Psychē have met or exceeded all of our expectations to date and I’m confident that they will continue to do so in the future.”

Ē.xtension Modules

Case Studies

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